BAIT
CACNA1A
BccA1, Cav2.1, rbA-1
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
GO Process (50)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- adult walking behavior [ISO]
- behavioral response to pain [ISO]
- calcium ion import [IDA, IMP]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IDA, IMP, ISO]
- calcium ion-dependent exocytosis [ISO]
- calcium ion-dependent exocytosis of neurotransmitter [ISO]
- cell death [ISO]
- cell growth [ISO]
- cellular chloride ion homeostasis [ISO]
- central nervous system neuron differentiation [ISO]
- cerebellar Purkinje cell differentiation [ISO]
- cerebellar Purkinje cell layer development [ISO]
- cerebellar molecular layer development [ISO]
- cerebellum maturation [ISO]
- dendrite morphogenesis [ISO]
- gamma-aminobutyric acid secretion [ISO]
- gamma-aminobutyric acid signaling pathway [ISO]
- glucose metabolic process [ISO]
- hormone metabolic process [ISO]
- membrane depolarization [ISO]
- membrane depolarization during action potential [IBA]
- musculoskeletal movement, spinal reflex action [ISO]
- negative regulation of hormone biosynthetic process [ISO]
- negative regulation of neuron apoptotic process [ISO]
- neurological system process [ISO]
- neuromuscular process [ISO]
- neuromuscular process controlling balance [ISO]
- neuromuscular synaptic transmission [ISO]
- neuron-neuron synaptic transmission [ISO]
- neurotransmitter metabolic process [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO, ISS]
- receptor clustering [ISO]
- regulation of acetylcholine secretion, neurotransmission [ISO]
- regulation of axonogenesis [ISO]
- regulation of calcium ion-dependent exocytosis [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane potential [ISO]
- response to pain [ISO]
- rhythmic synaptic transmission [ISO]
- sensory perception of pain [IMP]
- spinal cord motor neuron differentiation [ISO]
- sulfur amino acid metabolic process [ISO]
- synapse assembly [ISO]
- synaptic transmission [IMP, ISO]
- synaptic transmission, GABAergic [ISO]
- synaptic transmission, glutamatergic [ISO]
- thyroid hormone metabolic process [ISO]
- transmission of nerve impulse [ISO]
- vestibular nucleus development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RNF138
Rsd4, Trif, RSD-4
ring finger protein 138, E3 ubiquitin protein ligase
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Cav2.1 (P/Q-Type) Calcium Channels.
Voltage-gated CaV2.1 channels comprise a pore-forming α1A subunit with auxiliary α2δ and β subunits. CaV2.1 channels play an essential role in regulating synaptic signaling. Mutations in the human gene encoding the CaV2.1 subunit are associated with the cerebellar disease episodic ataxia type 2 (EA2). Several EA2-causing mutants exhibit impaired protein stability and exert dominant-negative suppression of CaV2.1 wild-type (WT) protein ... [more]
J. Neurosci. Mar. 01, 2017; 37(9);2485-2503 [Pubmed: 28167673]
Throughput
- Low Throughput
Curated By
- BioGRID