PREY

CDK5

PSSALRE
cyclin-dependent kinase 5
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

DNA binding protein dbpA binds Cdk5 and inhibits its activity.

Moorthamer M, Zumstein-Mecker S, Chaudhuri B

Progress in the cell cycle is governed by the activity of cyclin dependent kinases (Cdks). Unlike other Cdks, the Cdk5 catalytic subunit is found mostly in differentiated neurons. Interestingly, the only known protein that activates Cdk5 (i.e. p35) is expressed solely in the brain. It has been suggested that, besides its requirement in neuronal differentiation, Cdk5 activity is induced during ... [more]

FEBS Lett. Mar. 12, 1999; 446(2);343-50 [Pubmed: 10100871]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CDK5 YBX3
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Low-BioGRID
-

Curated By

  • BioGRID