KCNMA1
Gene Ontology Biological Process
- adult walking behavior [IMP]
- auditory receptor cell differentiation [IMP]
- cell maturation [IMP]
- cellular potassium ion homeostasis [ISO]
- circadian rhythm [IMP]
- eye blink reflex [IMP]
- locomotor rhythm [IMP]
- micturition [IMP, ISO]
- negative regulation of cell volume [IMP, ISO]
- neuromuscular process controlling balance [IMP]
- neuronal action potential [IMP]
- positive regulation of apoptotic process [ISO]
- potassium ion transmembrane transport [IBA, IGI, ISO]
- potassium ion transport [IDA, ISO]
- protein homooligomerization [IDA]
- protein homotetramerization [ISO]
- regulation of aldosterone metabolic process [IMP]
- regulation of ion transmembrane transport [IMP]
- regulation of membrane potential [IDA, IMP, ISO]
- regulation of vasodilation [ISO]
- relaxation of vascular smooth muscle [IMP]
- response to calcium ion [ISO]
- response to carbon monoxide [ISO]
- response to corticosteroid [ISO]
- response to estrogen [ISO]
- response to hypoxia [IDA, ISO]
- response to osmotic stress [ISO]
- response to pH [ISO]
- saliva secretion [IGI]
- sensory perception of sound [IMP]
- smooth muscle contraction involved in micturition [IMP, ISO]
- synaptic transmission [IMP]
- vasodilation [IMP]
Gene Ontology Molecular Function- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, IGI, IMP, ISO]
- large conductance calcium-activated potassium channel activity [IDA, IMP, ISO]
- potassium channel activity [IGI, IMP]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- voltage-gated potassium channel activity [IDA, IMP, ISO]
- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, IGI, IMP, ISO]
- large conductance calcium-activated potassium channel activity [IDA, IMP, ISO]
- potassium channel activity [IGI, IMP]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- voltage-gated potassium channel activity [IDA, IMP, ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- caveola [ISO]
- cell [IMP]
- cytoplasm [IDA]
- dendrite [ISO]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IC, IDA, ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [IDA]
- presynaptic active zone membrane [ISO]
- protein complex [ISO]
- terminal bouton [IDA]
- voltage-gated potassium channel complex [IGI, ISO]
FADD
Gene Ontology Biological Process
- T cell differentiation [TAS]
- T cell differentiation in thymus [IMP]
- T cell homeostasis [IMP]
- TRAIL-activated apoptotic signaling pathway [ISO]
- activation of cysteine-type endopeptidase activity [ISO]
- apoptotic process [ISO]
- apoptotic signaling pathway [ISO]
- cardiac muscle tissue development [TAS]
- defense response to virus [ISO]
- extrinsic apoptotic signaling pathway [IDA, ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- innate immune response [TAS]
- lymph node development [IGI]
- motor neuron apoptotic process [IMP]
- necroptotic signaling pathway [ISO]
- negative regulation of activation-induced cell death of T cells [IMP]
- negative regulation of necroptotic process [IGI]
- positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [IMP]
- positive regulation of T cell mediated cytotoxicity [IMP]
- positive regulation of activated T cell proliferation [IMP]
- positive regulation of adaptive immune response [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IGI, ISO]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IGI]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of macrophage differentiation [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of type I interferon-mediated signaling pathway [ISO]
- protein heterooligomerization [ISO]
- spleen development [IGI]
- thymus development [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The large conductance calcium-activated potassium channel affects extrinsic and intrinsic mechanisms of apoptosis.
The large-conductance calcium-activated K(+) or BK channel underlies electrical signals in a number of different cell types. Studies show that BK activity can also serve to regulate cellular homeostasis by protecting cells from apoptosis resulting from events such as ischemia. Recent coimmunoprecipitation studies, combined with mass spectrometry, suggest putative protein partners that interact with BK to regulate intrinsic and extrinsic ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNMA1 FADD | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FADD KCNMA1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FADD KCNMA1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID