SUV39H1
Gene Ontology Biological Process
- DNA packaging [TAS]
- cellular response to DNA damage stimulus [ISO]
- cellular response to hypoxia [ISO]
- chromatin silencing [TAS]
- chromatin silencing at rDNA [ISO]
- histone H3-K9 dimethylation [IMP]
- histone H3-K9 methylation [IDA, IGI, ISO]
- histone H3-K9 trimethylation [IMP]
- histone lysine methylation [IGI]
- negative regulation of circadian rhythm [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IMP]
- peptidyl-lysine methylation [IGI]
- protein methylation [TAS]
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- S-adenosylmethionine-dependent methyltransferase activity [ISO]
- histone methyltransferase activity [ISO]
- histone methyltransferase activity (H3-K9 specific) [IDA, ISO]
- histone-lysine N-methyltransferase activity [IDA, IGI, ISO]
- methyltransferase activity [IDA]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein methyltransferase activity [TAS]
- transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- S-adenosylmethionine-dependent methyltransferase activity [ISO]
- histone methyltransferase activity [ISO]
- histone methyltransferase activity (H3-K9 specific) [IDA, ISO]
- histone-lysine N-methyltransferase activity [IDA, IGI, ISO]
- methyltransferase activity [IDA]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein methyltransferase activity [TAS]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
CBX1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions.
The presence of H3K9me3 and heterochromatin protein 1 (HP1) are hallmarks of heterochromatin conserved in eukaryotes. The spreading and maintenance of H3K9me3 is effected by the functional interplay between the H3K9me3-specific histone methyltransferase Suv39h1 and HP1. This interplay is complex in mammals because the three HP1 isoforms, HP1α, β, and γ, are thought to play a redundant role in Suv39h1-dependent ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CBX1 SUV39H1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID