BAIT
CDH1
Arc-1, CD324, CDHE, ECAD, LCAM, UVO
cadherin 1, type 1, E-cadherin (epithelial)
GO Process (17)
GO Function (7)
GO Component (16)
Gene Ontology Biological Process
- adherens junction organization [IMP, TAS]
- apoptotic process [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to indole-3-methanol [IDA]
- cellular response to lithium ion [IDA]
- establishment of protein localization to plasma membrane [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- homophilic cell adhesion via plasma membrane adhesion molecules [NAS]
- negative regulation of cell-cell adhesion [IMP]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to plasma membrane [IDA]
- regulation of immune response [TAS]
- single organismal cell-cell adhesion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- aggresome [IDA]
- apical junction complex [IDA]
- catenin complex [IDA]
- cell junction [IDA, TAS]
- cell-cell adherens junction [IDA]
- cytoplasm [IDA]
- cytoplasmic side of plasma membrane [IDA]
- extracellular region [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of membrane [IDA]
- lateral plasma membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- trans-Golgi network [IMP]
Homo sapiens
PREY
PTPRJ
CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
protein tyrosine phosphatase, receptor type, J
GO Process (17)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- contact inhibition [NAS]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of T cell receptor signaling pathway [IDA, IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epidermal growth factor receptor signaling pathway [IMP]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of vascular permeability [IDA]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive chemotaxis [IDA]
- positive regulation of cell adhesion [IMP]
- positive regulation of focal adhesion assembly [IMP]
- positive regulation of protein kinase B signaling [IMP]
- regulation of cell adhesion [IMP]
Gene Ontology Molecular Function- beta-catenin binding [IPI]
- delta-catenin binding [IPI]
- gamma-catenin binding [IPI]
- mitogen-activated protein kinase binding [IPI]
- phosphatase activity [IDA, IMP]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine phosphatase activity [IDA, IMP]
- beta-catenin binding [IPI]
- delta-catenin binding [IPI]
- gamma-catenin binding [IPI]
- mitogen-activated protein kinase binding [IPI]
- phosphatase activity [IDA, IMP]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine phosphatase activity [IDA, IMP]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
E-cadherin-mediated cell-cell adhesion and signaling plays an essential role in development and maintenance of healthy epithelial tissues. Adhesiveness mediated by E-cadherin is conferred by its extracellular cadherin domains and is regulated by an assembly of intracellular adaptors and enzymes associated with its cytoplasmic tail. We used proximity biotinylation and quantitative proteomics to identify 561 proteins in the vicinity of the ... [more]
Sci Signal Dec. 02, 2014; 7(354);rs7 [Pubmed: 25468996]
Throughput
- High Throughput
Curated By
- BioGRID