BAIT

CDH1

Arc-1, CD324, CDHE, ECAD, LCAM, UVO
cadherin 1, type 1, E-cadherin (epithelial)
GO Process (17)
GO Function (7)
GO Component (16)
Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R

E-cadherin-mediated cell-cell adhesion and signaling plays an essential role in development and maintenance of healthy epithelial tissues. Adhesiveness mediated by E-cadherin is conferred by its extracellular cadherin domains and is regulated by an assembly of intracellular adaptors and enzymes associated with its cytoplasmic tail. We used proximity biotinylation and quantitative proteomics to identify 561 proteins in the vicinity of the ... [more]

Sci Signal Dec. 02, 2014; 7(354);rs7 [Pubmed: 25468996]

Throughput

  • High Throughput

Curated By

  • BioGRID