BAIT
CDH1
Arc-1, CD324, CDHE, ECAD, LCAM, UVO
cadherin 1, type 1, E-cadherin (epithelial)
GO Process (17)
GO Function (7)
GO Component (16)
Gene Ontology Biological Process
- adherens junction organization [IMP, TAS]
- apoptotic process [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to indole-3-methanol [IDA]
- cellular response to lithium ion [IDA]
- establishment of protein localization to plasma membrane [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- homophilic cell adhesion via plasma membrane adhesion molecules [NAS]
- negative regulation of cell-cell adhesion [IMP]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to plasma membrane [IDA]
- regulation of immune response [TAS]
- single organismal cell-cell adhesion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- aggresome [IDA]
- apical junction complex [IDA]
- catenin complex [IDA]
- cell junction [IDA, TAS]
- cell-cell adherens junction [IDA]
- cytoplasm [IDA]
- cytoplasmic side of plasma membrane [IDA]
- extracellular region [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of membrane [IDA]
- lateral plasma membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- trans-Golgi network [IMP]
Homo sapiens
PREY
DAB2IP
AF9Q34, AIP-1, AIP1, DIP1/2, RP11-298A17.1
DAB2 interacting protein
GO Process (65)
GO Function (20)
GO Component (11)
Gene Ontology Biological Process
- I-kappaB phosphorylation [ISS]
- activation of JUN kinase activity [IDA]
- activation of MAPKKK activity [IDA]
- cell motility involved in cerebral cortex radial glia guided migration [ISS]
- cellular protein catabolic process [IDA]
- cellular response to epidermal growth factor stimulus [ISS]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to tumor necrosis factor [IDA]
- cellular response to vascular endothelial growth factor stimulus [IDA, ISS]
- endothelial cell apoptotic process [TAS]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- layer formation in cerebral cortex [ISS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of G0 to G1 transition [IDA]
- negative regulation of GTPase activity [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of MAP kinase activity [IDA, IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of Ras GTPase activity [IMP]
- negative regulation of Ras protein signal transduction [IBA, IC]
- negative regulation of angiogenesis [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of catenin import into nucleus [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin catabolic process [IDA]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISS]
- negative regulation of epithelial cell migration [IMP, TAS]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of epithelial to mesenchymal transition [IDA, IMP]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of phosphatidylinositol 3-kinase activity [IDA]
- negative regulation of phosphatidylinositol 3-kinase signaling [IDA]
- negative regulation of protein phosphorylation [IMP, ISS]
- negative regulation of protein serine/threonine kinase activity [IDA, IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- negative regulation of vascular endothelial growth factor signaling pathway [ISS]
- neuron projection morphogenesis [ISS]
- positive regulation of JNK cascade [IDA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Ras GTPase activity [IBA]
- positive regulation of apoptotic process [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of dendrite development [ISS]
- positive regulation of neuron migration [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of proteasomal protein catabolic process [IMP]
- positive regulation of protein catabolic process [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA, IMP]
- positive regulation of synapse maturation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of ARF GTPase activity [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- regulation of p38MAPK cascade [ISS]
- regulation of protein complex assembly [IDA]
- transformed cell apoptotic process [TAS]
- tube formation [IMP]
- vascular endothelial growth factor receptor-2 signaling pathway [ISS]
Gene Ontology Molecular Function- 14-3-3 protein binding [IDA]
- Ras GTPase activator activity [IBA, ISS]
- SH3 domain binding [IDA]
- Toll-like receptor 4 binding [IDA]
- death receptor binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- phosphatidylinositol 3-kinase regulatory subunit binding [IDA]
- phosphatidylinositol-3-phosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- signaling adaptor activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI]
- 14-3-3 protein binding [IDA]
- Ras GTPase activator activity [IBA, ISS]
- SH3 domain binding [IDA]
- Toll-like receptor 4 binding [IDA]
- death receptor binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- phosphatidylinositol 3-kinase regulatory subunit binding [IDA]
- phosphatidylinositol-3-phosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- signaling adaptor activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI]
Gene Ontology Cellular Component
- axon [ISS]
- cerebellar mossy fiber [ISS]
- climbing fiber [ISS]
- cytoplasm [IDA]
- endocytic vesicle [IDA]
- extracellular vesicular exosome [IDA]
- intrinsic component of the cytoplasmic side of the plasma membrane [IBA]
- neuronal cell body [ISS]
- neuronal cell body membrane [ISS]
- parallel fiber [ISS]
- plasma membrane [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
E-cadherin-mediated cell-cell adhesion and signaling plays an essential role in development and maintenance of healthy epithelial tissues. Adhesiveness mediated by E-cadherin is conferred by its extracellular cadherin domains and is regulated by an assembly of intracellular adaptors and enzymes associated with its cytoplasmic tail. We used proximity biotinylation and quantitative proteomics to identify 561 proteins in the vicinity of the ... [more]
Sci Signal Dec. 02, 2014; 7(354);rs7 [Pubmed: 25468996]
Throughput
- High Throughput
Curated By
- BioGRID