BAIT
DDIAS
C11orf82, noxin
DNA damage-induced apoptosis suppressor
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ACTN1
BDPLT15
actinin, alpha 1
GO Process (8)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells.
DNA damage-induced apoptosis suppressor (DDIAS) rescues lung cancer cells from apoptosis in response to DNA damage. DDIAS is transcriptionally activated by NFATc1 and EGF-mediated ERK5/MEF2B, leading to cisplatin resistance and cell invasion. Therefore, DDIAS is suggested as a therapeutic target for lung cancer. Here, we report that DDIAS stability is regulated by E3 U-box ubiquitin ligase carboxyl terminus of HSP70-interacting ... [more]
Cell Death Dis Jan. 12, 2017; 8(1);e2554 [Pubmed: 28079882]
Throughput
- Low Throughput
Curated By
- BioGRID