PLA2G4A
Gene Ontology Biological Process
- arachidonic acid metabolic process [ISO]
- arachidonic acid secretion [IDA, IMP]
- cellular response to antibiotic [IDA]
- decidualization [ISO]
- icosanoid biosynthetic process [IMP]
- ovulation from ovarian follicle [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of prostaglandin biosynthetic process [ISO]
- positive regulation of vesicle fusion [ISO]
- regulation of cell proliferation [IGI]
- response to calcium ion [ISO]
- response to organic substance [ISO]
- surfactant homeostasis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDK2
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- cellular response to insulin stimulus [ISO]
- histone phosphorylation [ISO]
- positive regulation of DNA-dependent DNA replication initiation [IGI]
- positive regulation of cell proliferation [ISO]
- positive regulation of transcription, DNA-templated [IGI]
- potassium ion transport [IGI]
- protein phosphorylation [IDA]
- regulation of cell cycle [IDA, ISO]
- regulation of gene silencing [ISO]
- response to cAMP [ISO]
- response to electrical stimulus [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Cajal body [ISO]
- X chromosome [IDA]
- Y chromosome [IDA]
- chromosome, telomeric region [IDA]
- condensed chromosome [IDA]
- cyclin-dependent protein kinase holoenzyme complex [IPI, ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- endosome [ISO]
- intracellular membrane-bounded organelle [ISO]
- nucleus [IDA, ISO]
- transcription factor complex [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.
The G2-to-M transition (or prophase) checkpoint of the cell cycle is a critical regulator of mitotic entry. SIRT2, a tumor suppressor gene, contributes to the control of this checkpoint by blocking mitotic entry under cellular stress. However, the mechanism underlying both SIRT2 activation and regulation of the G2-to-M transition remains largely unknown. Here, we report the formation of a multiprotein ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID