BAIT
BAD
AI325008, Bbc2
BCL2-associated agonist of cell death
GO Process (39)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- ADP metabolic process [IMP]
- ATP metabolic process [IMP]
- activation of cysteine-type endopeptidase activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- apoptotic process [ISO]
- apoptotic signaling pathway [IDA, IMP]
- cell proliferation [IDA]
- cellular process regulating host cell cycle in response to virus [IDA]
- cellular response to nicotine [ISO]
- cellular response to organic substance [ISO]
- cytokine-mediated signaling pathway [IDA]
- extrinsic apoptotic signaling pathway [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA, IGI, IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- glucose catabolic process [IMP]
- glucose homeostasis [IMP]
- intrinsic apoptotic signaling pathway [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA, IMP]
- pore complex assembly [ISO]
- positive regulation of B cell differentiation [IMP]
- positive regulation of T cell differentiation [IMP]
- positive regulation of apoptotic process [IDA, ISO]
- positive regulation of apoptotic process by virus [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of glucokinase activity [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of mitochondrial membrane potential [IMP]
- positive regulation of neuron death [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- positive regulation of type B pancreatic cell development [IMP]
- regulation of apoptotic process [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- release of cytochrome c from mitochondria [IMP]
- suppression by virus of host apoptotic process [IDA, IMP]
- type B pancreatic cell proliferation [IMP]
Gene Ontology Molecular Function- cysteine-type endopeptidase activator activity involved in apoptotic process [IDA, ISO]
- lipid binding [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
- protein phosphatase binding [IPI]
- cysteine-type endopeptidase activator activity involved in apoptotic process [IDA, ISO]
- lipid binding [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
- protein phosphatase binding [IPI]
Gene Ontology Cellular Component
Mus musculus
PREY
BCL2L1
Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, RP23-106A3.4
BCL2-like 1
GO Process (41)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- apoptotic process in bone marrow [IMP]
- cell proliferation [IDA]
- cellular process regulating host cell cycle in response to virus [IMP]
- cellular response to alkaloid [IDA]
- cellular response to amino acid stimulus [IMP]
- cellular response to gamma radiation [IMP]
- cytokinesis [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- fertilization [IGI]
- germ cell development [IGI, IMP]
- growth [IMP]
- hepatocyte apoptotic process [IMP]
- in utero embryonic development [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- male gonad development [IMP]
- mitochondrion morphogenesis [IGI]
- mitotic cell cycle checkpoint [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IDA, IGI, IMP, ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of establishment of protein localization to plasma membrane [ISO]
- negative regulation of execution phase of apoptosis [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of neuron apoptotic process [IDA, IGI, IMP]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- neuron apoptotic process [IGI, IMP]
- ovarian follicle development [IGI, IMP, ISO]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of apoptotic process [ISO]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of mitochondrial membrane potential [ISO]
- release of cytochrome c from mitochondria [IGI, ISO]
- response to cycloheximide [IDA]
- response to cytokine [ISO]
- response to ischemia [ISO]
- response to radiation [IMP]
- response to virus [IDA]
- spermatogenesis [IGI]
- suppression by virus of host apoptotic process [ISO]
Gene Ontology Molecular Function- BH domain binding [ISO]
- BH3 domain binding [ISO]
- MDM2/MDM4 family protein binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA]
- protein kinase binding [ISO]
- BH domain binding [ISO]
- BH3 domain binding [ISO]
- MDM2/MDM4 family protein binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.
The anticoagulant factor protein S (PS) protects neurons from hypoxic/ischemic injury. However, molecular mechanisms mediating PS protection in injured neurons remain unknown. Here, we show mouse recombinant PS protects dose-dependently mouse cortical neurons from excitotoxic NMDA-mediated neuritic bead formation and apoptosis by activating the phosphatidylinositol 3-kinase (PI3K)-Akt pathway (EC(50) = 26 ± 4 nm). PS stimulated phosphorylation of Bad and ... [more]
J. Neurosci. Nov. 17, 2010; 30(46);15521-34 [Pubmed: 21084607]
Throughput
- Low Throughput
Curated By
- BioGRID