AKT1
Gene Ontology Biological Process
- activation-induced cell death of T cells [ISO]
- aging [ISO]
- anagen [IMP]
- apoptotic mitochondrial changes [IDA]
- cell projection organization [ISO]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to hypoxia [ISO]
- cellular response to insulin stimulus [IDA, IMP, ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to organic cyclic compound [ISO]
- cellular response to peptide [IDA]
- cellular response to prostaglandin E stimulus [IDA]
- cytoskeleton organization [TAS]
- execution phase of apoptosis [IDA]
- germ cell development [IDA]
- glucose homeostasis [IMP]
- glucose metabolic process [IMP]
- glucose transport [IMP]
- glycogen biosynthetic process [ISO]
- glycogen cell differentiation involved in embryonic placenta development [IMP]
- glycogen metabolic process [IMP]
- inflammatory response [IDA]
- insulin receptor signaling pathway [IMP, ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [IMP]
- maternal placenta development [IMP]
- negative regulation of JNK cascade [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of autophagy [ISO]
- negative regulation of cell size [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of fatty acid beta-oxidation [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- osteoblast differentiation [IGI]
- peptidyl-serine phosphorylation [IDA, ISO]
- peripheral nervous system myelin maintenance [IMP]
- phosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of sodium ion transport [IDA, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of vasoconstriction [ISO]
- protein catabolic process [IDA]
- protein import into nucleus, translocation [ISO]
- protein kinase B signaling [IGI]
- protein phosphorylation [IDA, ISO]
- protein ubiquitination [IDA]
- regulation of cell migration [ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of myelination [IMP]
- regulation of neuron projection development [IDA]
- regulation of protein localization [IDA, ISO]
- response to UV-A [ISO]
- response to fluid shear stress [ISO]
- response to food [IDA]
- response to hormone [IDA]
- signal transduction [ISO]
- striated muscle cell differentiation [IGI]
- translation [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
GSK3A
Gene Ontology Biological Process
- cardiac left ventricle morphogenesis [IMP]
- cell migration [IGI]
- cellular response to insulin stimulus [ISO]
- cellular response to interleukin-3 [IDA]
- cellular response to lithium ion [IDA]
- cellular response to organic cyclic compound [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- hypermethylation of CpG island [IMP]
- insulin receptor signaling pathway [IDA]
- negative regulation of TOR signaling [IMP]
- negative regulation of cell growth involved in cardiac muscle cell development [IMP]
- negative regulation of glucose import [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of transferase activity [ISO]
- positive regulation of adrenergic receptor signaling pathway [IMP]
- positive regulation of cAMP biosynthetic process [IMP]
- positive regulation of glycogen (starch) synthase activity [IMP]
- positive regulation of heart contraction [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of gene expression by genetic imprinting [IMP]
- regulation of systemic arterial blood pressure [IMP]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.
The anticoagulant factor protein S (PS) protects neurons from hypoxic/ischemic injury. However, molecular mechanisms mediating PS protection in injured neurons remain unknown. Here, we show mouse recombinant PS protects dose-dependently mouse cortical neurons from excitotoxic NMDA-mediated neuritic bead formation and apoptosis by activating the phosphatidylinositol 3-kinase (PI3K)-Akt pathway (EC(50) = 26 ± 4 nm). PS stimulated phosphorylation of Bad and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AKT1 GSK3A | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1104891 | |
| AKT1 GSK3A | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1028265 |
Curated By
- BioGRID