AATF
Gene Ontology Biological Process
- cell adhesion [ISO]
- cellular response to DNA damage stimulus [ISO]
- embryonic cleavage [ISO]
- negative regulation of amyloid precursor protein biosynthetic process [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- negative regulation of superoxide anion generation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of mitotic cell cycle [ISO]
- ribosome biogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- centrosome [ISO]
- cytoplasm [IDA, ISO]
- focal adhesion [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
MAPT
Gene Ontology Biological Process
- adult walking behavior [ISO]
- apoptotic process [IDA]
- axon cargo transport [ISO]
- axon extension [ISO]
- axonogenesis [ISO]
- brain development [IEP]
- female pregnancy [IEP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IDA]
- microtubule cytoskeleton organization [ISO, ISS]
- microtubule-based process [NAS]
- mitochondrion transport along microtubule [ISO]
- negative regulation of intracellular transport [ISO]
- neuron differentiation [NAS]
- neuron migration [ISO]
- positive regulation of axon extension [ISO, ISS]
- positive regulation of microtubule polymerization [ISO, ISS]
- regulation of autophagy [ISO]
- regulation of microtubule-based movement [ISO]
- response to nutrient [IDA]
- response to organic substance [IDA]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- apolipoprotein binding [ISO]
- enzyme binding [IPI, ISO]
- lipoprotein particle binding [ISO]
- microtubule binding [IDA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IMP]
- protein kinase binding [IPI, ISO]
- protein phosphatase 2A binding [IPI]
- SH3 domain binding [ISO]
- apolipoprotein binding [ISO]
- enzyme binding [IPI, ISO]
- lipoprotein particle binding [ISO]
- microtubule binding [IDA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IMP]
- protein kinase binding [IPI, ISO]
- protein phosphatase 2A binding [IPI]
Gene Ontology Cellular Component
- axon [IDA, ISO, ISS]
- axonal growth cone [IDA]
- axoneme [ISO]
- cell [ISO]
- cytoplasm [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- growth cone [ISO, ISS]
- intracellular [ISO]
- microtubule cytoskeleton [ISO]
- neuron projection [IDA]
- nuclear periphery [ISO]
- nucleus [ISO]
- plasma membrane [ISO, ISS]
- postsynaptic density [ISO]
- tubulin complex [ISO, ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis.
Che-1 is a recently identified human Rb binding protein that inhibits the Rb growth-suppressing function and regulates cell proliferation. Che-1 contacts the Rb and competes with HDAC1 for Rb-binding site, removing HDAC1 from the Rb/E2F cell cycle-regulated promoters. We have investigated the expression of Che-1 in neuronal cells and we showed that Che-1 directly interacts with Tau. Tau is a ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAPT AATF | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID