AXL
Gene Ontology Biological Process
- apoptotic cell clearance [IGI, IMP]
- blood vessel remodeling [IMP]
- cell differentiation [ISO]
- cellular response to extracellular stimulus [IDA]
- cellular response to hydrogen peroxide [ISO]
- cellular response to interferon-alpha [ISO]
- cellular response to lipopolysaccharide [ISO]
- enzyme linked receptor protein signaling pathway [IGI]
- erythrocyte homeostasis [IGI, IMP]
- forebrain cell migration [IGI]
- inflammatory response [IMP]
- natural killer cell differentiation [IGI]
- negative regulation of apoptotic process [IGI, IMP, ISO]
- negative regulation of dendritic cell apoptotic process [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of lymphocyte activation [IGI]
- negative regulation of neuron apoptotic process [IGI, IMP]
- negative regulation of tumor necrosis factor production [IGI]
- neuron migration [IGI, IMP]
- ovulation cycle [IGI]
- phagocytosis [IGI, ISO]
- platelet activation [IMP]
- positive regulation of cytokine-mediated signaling pathway [ISO]
- positive regulation of natural killer cell differentiation [ISO]
- positive regulation of protein kinase B signaling [IMP, ISO]
- protein kinase B signaling [IGI, IMP]
- secretion by cell [IMP]
- spermatogenesis [IGI]
- substrate adhesion-dependent cell spreading [IMP]
- vagina development [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRB2
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- aging [ISO]
- anatomical structure formation involved in morphogenesis [IMP]
- branching involved in labyrinthine layer morphogenesis [IMP]
- cell differentiation [IMP]
- cellular response to ionizing radiation [ISO]
- fibroblast growth factor receptor signaling pathway [IGI]
- insulin receptor signaling pathway [ISO]
- positive regulation of actin filament polymerization [IGI]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of signal transduction [IDA]
- protein heterooligomerization [ISO]
- receptor internalization [ISO]
- regulation of MAPK cascade [IGI]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- SH3/SH2 adaptor activity [IDA]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- identical protein binding [ISO]
- insulin receptor substrate binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [IPI]
- SH3 domain binding [ISO]
- SH3/SH2 adaptor activity [IDA]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- identical protein binding [ISO]
- insulin receptor substrate binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.
Axl is a receptor tyrosine kinase implicated in cell survival following growth factor withdrawal and other stressors. The binding of Axl's ligand, growth arrest-specific protein 6 (Gas6), results in Axl autophosphorylation, recruitment of signaling molecules, and activation of downstream survival pathways. Pull-down assays and immunoprecipitations using wildtype and mutant Axl transfected cells determined that Axl directly binds growth factor receptor-bound ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID