BAIT
RET
CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
ret proto-oncogene
GO Process (18)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- Peyer's patch morphogenesis [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- cellular response to retinoic acid [IMP]
- lymphocyte migration into lymphoid organs [ISS]
- membrane protein proteolysis [IDA]
- neuron cell-cell adhesion [IMP]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP, TAS]
- positive regulation of metanephric glomerulus development [ISS]
- positive regulation of neuron projection development [IMP]
- positive regulation of transcription, DNA-templated [ISS]
- posterior midgut development [TAS]
- protein phosphorylation [TAS]
- regulation of cell adhesion [IDA]
- response to pain [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PTPRR
EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ
protein tyrosine phosphatase, receptor type, R
GO Process (7)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein interaction (PPI) approaches, the membrane yeast two-hybrid (MYTH) and the mammalian membrane two-hybrid (MaMTH), to map the PPIs between human RTKs and phosphatases. The resulting RTK-phosphatase interactome reveals a considerable number of previously unidentified interactions and suggests specific roles ... [more]
Mol. Cell Jan. 19, 2017; 65(2);347-360 [Pubmed: 28065597]
Throughput
- Low Throughput
Additional Notes
- MYTH assay
- Membrane Yeast Two-hybrid conducted
Curated By
- BioGRID