KDR
Gene Ontology Biological Process
- angiogenesis [TAS]
- calcium-mediated signaling using intracellular calcium source [IMP]
- cell migration involved in sprouting angiogenesis [ISS]
- cellular response to vascular endothelial growth factor stimulus [IDA, IMP]
- embryonic hemopoiesis [ISS]
- endothelium development [ISS]
- extracellular matrix organization [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of endothelial cell apoptotic process [IDA]
- peptidyl-tyrosine autophosphorylation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of MAPK cascade [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of vasculogenesis [ISS]
- protein autophosphorylation [IDA]
- regulation of cell shape [IDA]
- signal transduction by phosphorylation [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IMP, TAS]
- vascular endothelial growth factor signaling pathway [IDA]
- vasculogenesis [ISS]
Gene Ontology Molecular Function- Hsp90 protein binding [TAS]
- growth factor binding [IPI]
- integrin binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor signaling protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
- Hsp90 protein binding [TAS]
- growth factor binding [IPI]
- integrin binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor signaling protein tyrosine kinase activity [TAS]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
Gene Ontology Cellular Component
PTPN11
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- atrioventricular canal development [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- brain development [IMP]
- cytokine-mediated signaling pathway [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- face morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- genitalia development [IMP]
- heart development [IMP]
- innate immune response [TAS]
- inner ear development [IMP]
- insulin receptor signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of glucose import in response to insulin stimulus [IDA]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein interaction (PPI) approaches, the membrane yeast two-hybrid (MYTH) and the mammalian membrane two-hybrid (MaMTH), to map the PPIs between human RTKs and phosphatases. The resulting RTK-phosphatase interactome reveals a considerable number of previously unidentified interactions and suggests specific roles ... [more]
Throughput
- Low Throughput
Additional Notes
- MYTH assay
- Membrane Yeast Two-hybrid conducted
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
KDR PTPN11 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
KDR PTPN11 | Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe. | Low | - | BioGRID | - |
Curated By
- BioGRID