BAIT
DUSP19
DUSP17, LMWDSP3, SKRP1, TS-DSP1
dual specificity phosphatase 19
GO Process (9)
GO Function (5)
GO Component (0)
Gene Ontology Biological Process
- JNK cascade [IBA]
- negative regulation of JNK cascade [ISS]
- negative regulation of JUN kinase activity [ISS]
- negative regulation of protein kinase activity [ISS]
- positive regulation of JNK cascade [ISS]
- positive regulation of JUN kinase activity [ISS]
- positive regulation of MAPK cascade [ISS]
- positive regulation of protein kinase activity [ISS]
- protein dephosphorylation [IBA]
Homo sapiens
PREY
ACTG1
ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176
actin, gamma 1
GO Process (10)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- adherens junction organization [TAS]
- axon guidance [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component movement [TAS]
- innate immune response [TAS]
- membrane organization [TAS]
- platelet aggregation [IMP]
- retina homeostasis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence ... [more]
Cell Rep Nov. 22, 2016; 17(9);2488-2501 [Pubmed: 27880917]
Throughput
- High Throughput
Curated By
- BioGRID