BAIT
PPM1B
PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
protein phosphatase, Mg2+/Mn2+ dependent, 1B
GO Process (8)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- N-terminal protein myristoylation [ISS]
- cytokine-mediated signaling pathway [TAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of NF-kappaB import into nucleus [IMP]
- negative regulation of defense response to virus [IMP]
- negative regulation of interferon-beta production [IMP]
- peptidyl-threonine dephosphorylation [IDA]
- protein dephosphorylation [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
SPTBN1
ELF, HEL102, SPTB2, betaSpII
spectrin, beta, non-erythrocytic 1
GO Process (6)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence ... [more]
Cell Rep Nov. 22, 2016; 17(9);2488-2501 [Pubmed: 27880917]
Throughput
- High Throughput
Curated By
- BioGRID