BAIT
PPP3CA
CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
protein phosphatase 3, catalytic subunit, alpha isozyme
GO Process (10)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell activation [TAS]
- calcineurin-NFAT signaling cascade [IDA]
- cellular response to drug [IDA]
- dephosphorylation [TAS]
- innate immune response [TAS]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein dephosphorylation [IDA, NAS]
- response to calcium ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcineurin complex [IDA, NAS]
- cytoplasm [IDA]
- cytosol [TAS]
- nucleoplasm [IDA, TAS]
Homo sapiens
PREY
LBH
limb bud and heart development
GO Process (2)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence ... [more]
Cell Rep Nov. 22, 2016; 17(9);2488-2501 [Pubmed: 27880917]
Throughput
- High Throughput
Curated By
- BioGRID