BAIT
PTPN5
PTPSTEP, STEP
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
GO Process (2)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HLA-A
HLAA, DAQB-90C11.16-002
major histocompatibility complex, class I, A
GO Process (17)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [IDA]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cytokine-mediated signaling pathway [TAS]
- detection of bacterium [IMP]
- immune response [IMP, NAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of T cell mediated cytotoxicity [IDA]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of memory T cell activation [IDA]
- protection from natural killer cell mediated cytotoxicity [IDA]
- regulation of defense response to virus by virus [TAS]
- regulation of immune response [TAS]
- type I interferon signaling pathway [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi apparatus [IDA, ISS]
- Golgi medial cisterna [IDA]
- Golgi membrane [TAS]
- MHC class I protein complex [IDA, ISS]
- cell surface [IDA, ISS]
- early endosome membrane [TAS]
- endoplasmic reticulum [IDA, ISS]
- endoplasmic reticulum exit site [IDA]
- extracellular vesicular exosome [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- integral component of plasma membrane [NAS]
- membrane [IDA]
- phagocytic vesicle membrane [TAS]
- plasma membrane [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence ... [more]
Cell Rep Nov. 22, 2016; 17(9);2488-2501 [Pubmed: 27880917]
Throughput
- High Throughput
Curated By
- BioGRID