BAIT
PTPN7
BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI, RP11-294K24.3
protein tyrosine phosphatase, non-receptor type 7
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
OPA1
MGM1, NPG, NTG, largeG
optic atrophy 1 (autosomal dominant)
GO Process (11)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- axon transport of mitochondrion [TAS]
- cellular senescence [IDA]
- inner mitochondrial membrane organization [IDA]
- mitochondrial fission [TAS]
- mitochondrial fusion [IDA, IMP, TAS]
- mitochondrial genome maintenance [IMP]
- mitochondrion organization [IMP, NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IGI]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence ... [more]
Cell Rep Nov. 22, 2016; 17(9);2488-2501 [Pubmed: 27880917]
Throughput
- High Throughput
Curated By
- BioGRID