BAIT
PTPRA
HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA, RP4-534B8.1
protein tyrosine phosphatase, receptor type, A
GO Process (2)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KCNMA1
BKTM, KCa1.1, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, mSLO1, RP11-443A13.1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
GO Process (14)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cellular potassium ion homeostasis [IDA]
- micturition [IDA]
- negative regulation of cell volume [IDA]
- positive regulation of apoptotic process [IMP]
- potassium ion transmembrane transport [IBA, IDA]
- potassium ion transport [IDA]
- regulation of membrane potential [IDA]
- response to calcium ion [IDA]
- response to carbon monoxide [IDA, IMP]
- response to hypoxia [IDA]
- response to osmotic stress [IDA]
- smooth muscle contraction involved in micturition [IDA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence ... [more]
Cell Rep Nov. 22, 2016; 17(9);2488-2501 [Pubmed: 27880917]
Throughput
- High Throughput
Curated By
- BioGRID