BAIT
SSH1
SSH1L
slingshot protein phosphatase 1
GO Process (8)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- cell morphogenesis [IMP]
- cellular response to ATP [IDA]
- protein dephosphorylation [IMP]
- regulation of actin polymerization or depolymerization [IBA]
- regulation of axonogenesis [IBA]
- regulation of cellular protein metabolic process [IDA]
- regulation of lamellipodium assembly [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SCIN
scinderin
GO Process (8)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- actin filament severing [IMP]
- actin nucleation [ISS]
- calcium ion-dependent exocytosis [ISS]
- negative regulation of cell proliferation [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of megakaryocyte differentiation [IMP]
- positive regulation of secretion [ISS]
- regulation of chondrocyte differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence ... [more]
Cell Rep Nov. 22, 2016; 17(9);2488-2501 [Pubmed: 27880917]
Throughput
- High Throughput
Curated By
- BioGRID