BAIT
PTPRK
R-PTP-kappa, RP3-480J14.1
protein tyrosine phosphatase, receptor type, K
GO Process (15)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- cell adhesion [IMP]
- cell migration [IMP]
- cellular response to UV [IDA]
- cellular response to reactive oxygen species [IDA]
- focal adhesion assembly [IMP]
- negative regulation of cell cycle [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of keratinocyte proliferation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- peptidyl-tyrosine dephosphorylation [IDA, NAS]
- protein dephosphorylation [IDA]
- protein localization to cell surface [IDA]
- signal transduction [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MINK1
B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta
misshapen-like kinase 1
GO Process (14)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- JNK cascade [TAS]
- actin cytoskeleton reorganization [IMP]
- dendrite morphogenesis [ISS]
- intracellular signal transduction [ISS]
- multicellular organismal development [ISS]
- positive regulation of JNK cascade [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of cell migration [IMP]
- regulation of cell-cell adhesion [IMP]
- regulation of cell-matrix adhesion [IMP]
- response to stress [ISS]
- synaptic transmission [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence ... [more]
Cell Rep Nov. 22, 2016; 17(9);2488-2501 [Pubmed: 27880917]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID