BAIT
PTPRM
PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu
protein tyrosine phosphatase, receptor type, M
GO Process (11)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- negative regulation of angiogenesis [IMP]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- neuron projection development [IDA, IMP]
- peptidyl-tyrosine dephosphorylation [IDA]
- protein dephosphorylation [IDA]
- response to drug [IDA]
- retina layer formation [IMP]
- retinal ganglion cell axon guidance [IDA]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LMTK2
AATYK2, BREK, KPI-2, KPI2, LMR2, PPP1R100, cprk
lemur tyrosine kinase 2
GO Process (9)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- early endosome to late endosome transport [IMP]
- endocytic recycling [IMP]
- negative regulation of catalytic activity [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- receptor recycling [IMP]
- transferrin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence ... [more]
Cell Rep Nov. 22, 2016; 17(9);2488-2501 [Pubmed: 27880917]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID