BAIT
SBF2
CMT4B2, DENND7B, MTMR13
SET binding factor 2
GO Process (2)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
H2AFY2
macroH2A2, RP11-367H5.3
H2A histone family, member Y2
GO Process (7)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- brain development [IMP]
- dosage compensation [IDA]
- establishment of protein localization to chromatin [IMP]
- negative regulation of gene expression, epigenetic [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [IGI]
- regulation of cell growth [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence ... [more]
Cell Rep Nov. 22, 2016; 17(9);2488-2501 [Pubmed: 27880917]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID