BAIT
DUSP2
PAC-1, PAC1
dual specificity phosphatase 2
GO Process (4)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
DUSP3
VHR
dual specificity phosphatase 3
GO Process (23)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- inactivation of MAPK activity [IMP]
- innate immune response [TAS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of JNK cascade [IDA, IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of T cell activation [IDA]
- negative regulation of T cell receptor signaling pathway [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA]
- positive regulation of mitotic cell cycle [IMP]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.
Protein tyrosine phosphorylation, which plays a vital role in a variety of human cellular processes, is coordinated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Genomic studies provide compelling evidence that PTPs are frequently mutated in various human cancers, suggesting that they have important roles in tumor suppression. However, the cellular functions and regulatory machineries of most PTPs are ... [more]
Mol. Cell Proteomics Sep. 01, 2016; 15(9);3030-44 [Pubmed: 27432908]
Throughput
- High Throughput
Additional Notes
- high-confidence candidate interacting protein
Curated By
- BioGRID