BAIT
DUSP2
PAC-1, PAC1
dual specificity phosphatase 2
GO Process (4)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
VPS4A
SKD1, SKD1A, SKD2, VPS4, VPS4-1
vacuolar protein sorting 4 homolog A (S. cerevisiae)
GO Process (16)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- ATP catabolic process [NAS]
- abscission [IMP]
- cytokinesis [IDA]
- cytokinesis checkpoint [IMP]
- cytoplasmic microtubule organization [IBA]
- endosomal transport [IMP, TAS]
- membrane organization [TAS]
- negative regulation of cytokinesis [IMP]
- positive regulation of exosomal secretion [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]
- vacuole organization [IBA]
- vesicle-mediated transport [IDA]
- viral budding via host ESCRT complex [IGI]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.
Protein tyrosine phosphorylation, which plays a vital role in a variety of human cellular processes, is coordinated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Genomic studies provide compelling evidence that PTPs are frequently mutated in various human cancers, suggesting that they have important roles in tumor suppression. However, the cellular functions and regulatory machineries of most PTPs are ... [more]
Mol. Cell Proteomics Sep. 01, 2016; 15(9);3030-44 [Pubmed: 27432908]
Throughput
- High Throughput
Additional Notes
- high-confidence candidate interacting protein
Curated By
- BioGRID