BAIT
CYP2A7
CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4
cytochrome P450, family 2, subfamily A, polypeptide 7
GO Process (5)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function- arachidonic acid epoxygenase activity [IBA]
- heme binding [IBA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [TAS]
- steroid hydroxylase activity [IBA]
- arachidonic acid epoxygenase activity [IBA]
- heme binding [IBA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [TAS]
- steroid hydroxylase activity [IBA]
Gene Ontology Cellular Component
Homo sapiens
PREY
CYP2A6
CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6
GO Process (9)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- coumarin catabolic process [IDA]
- coumarin metabolic process [IDA]
- drug metabolic process [IDA, IMP]
- epoxygenase P450 pathway [IBA]
- exogenous drug catabolic process [IDA]
- oxidation-reduction process [IBA]
- small molecule metabolic process [TAS]
- steroid metabolic process [IMP]
- xenobiotic metabolic process [IBA, TAS]
Gene Ontology Molecular Function- arachidonic acid epoxygenase activity [IBA]
- coumarin 7-hydroxylase activity [IDA]
- enzyme binding [IPI]
- heme binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
- arachidonic acid epoxygenase activity [IBA]
- coumarin 7-hydroxylase activity [IDA]
- enzyme binding [IPI]
- heme binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [IBA]
- steroid hydroxylase activity [IBA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 1.0 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 1.0, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID