NLGN3
Gene Ontology Biological Process
- adult behavior [IMP]
- axon extension [ISS]
- learning [IMP]
- metabolic process [IBA]
- neuron cell-cell adhesion [IBA, ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- receptor-mediated endocytosis [ISS]
- regulation of inhibitory postsynaptic membrane potential [ISS]
- regulation of respiratory gaseous exchange by neurological system process [ISS]
- regulation of synaptic transmission [IBA, ISS]
- rhythmic synaptic transmission [ISS]
- social behavior [IMP]
- synapse assembly [IBA, ISS]
- synapse organization [IMP]
- vocalization behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NLGN4X
Gene Ontology Biological Process
- adult behavior [IMP]
- brainstem development [ISS]
- cell-cell junction organization [NAS]
- cerebellum development [ISS]
- learning [IMP]
- metabolic process [IBA]
- negative regulation of excitatory postsynaptic membrane potential [IDA]
- neuron cell-cell adhesion [TAS]
- neuron differentiation [NAS]
- organ growth [ISS]
- presynaptic membrane assembly [IDA]
- regulation of synaptic transmission [IBA]
- social behavior [IMP]
- synapse organization [IMP, NAS]
- vocalization behavior [IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 1.0 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 1.0, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NLGN3 NLGN4X | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3126145 | |
| NLGN3 NLGN4X | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3252687 |
Curated By
- BioGRID