GTF2H2C_2
ERCC3
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [TAS]
- DNA repair [IMP, TAS]
- DNA topological change [IMP]
- apoptotic process [IMP]
- gene expression [TAS]
- hair cell differentiation [IMP]
- nucleotide-excision repair [IMP, TAS]
- nucleotide-excision repair, DNA damage removal [TAS]
- nucleotide-excision repair, DNA duplex unwinding [IMP]
- nucleotide-excision repair, DNA incision [IMP]
- positive regulation of apoptotic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of viral transcription [TAS]
- protein localization [IMP]
- regulation of mitotic cell cycle phase transition [IMP]
- response to UV [IMP]
- response to oxidative stress [IMP]
- termination of RNA polymerase I transcription [TAS]
- transcription elongation from RNA polymerase I promoter [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase I promoter [TAS]
- transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription-coupled nucleotide-excision repair [IDA, TAS]
- viral process [TAS]
Gene Ontology Molecular Function- 3'-5' DNA helicase activity [IDA, IMP]
- ATPase activity [IDA]
- DNA binding [TAS]
- DNA-dependent ATPase activity [IDA, IMP]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- damaged DNA binding [NAS]
- protein C-terminus binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- transcription factor binding [IDA]
- 3'-5' DNA helicase activity [IDA, IMP]
- ATPase activity [IDA]
- DNA binding [TAS]
- DNA-dependent ATPase activity [IDA, IMP]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- damaged DNA binding [NAS]
- protein C-terminus binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- transcription factor binding [IDA]
Gene Ontology Cellular Component
- holo TFIIH complex [IDA, TAS]
- nucleoplasm [IDA, TAS]
- nucleus [TAS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999999919 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999999919, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GTF2H2C_2 ERCC3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 1191022 | |
| GTF2H2C_2 ERCC3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3287700 | |
| GTF2H2C_2 ERCC3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3096287 | |
| ERCC3 GTF2H2C_2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 1 | BioGRID | 1262834 |
Curated By
- BioGRID