ERCC6L
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SIX1
Gene Ontology Biological Process
- branching involved in ureteric bud morphogenesis [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic skeletal system morphogenesis [ISS]
- epithelial cell differentiation [ISS]
- generation of neurons [ISS]
- inner ear development [ISS]
- inner ear morphogenesis [ISS]
- kidney development [ISS]
- mesonephric tubule formation [ISS]
- metanephric mesenchyme development [ISS]
- myoblast migration [ISS]
- negative regulation of neuron apoptotic process [ISS]
- organ induction [ISS]
- pattern specification process [ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of ureteric bud formation [ISS]
- protein localization to nucleus [IDA]
- regulation of branch elongation involved in ureteric bud branching [ISS]
- regulation of neuron differentiation [ISS]
- regulation of transcription, DNA-templated [ISS]
- skeletal muscle tissue development [ISS]
- thymus development [ISS]
- thyroid gland development [ISS]
- ureteric bud development [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999999204 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999999204, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ERCC6L SIX1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3032143 |
Curated By
- BioGRID