TNFSF11
Gene Ontology Biological Process
- TNFSF11-mediated signaling pathway [IDA]
- cytokine-mediated signaling pathway [IDA]
- immune response [NAS]
- monocyte chemotaxis [IDA]
- osteoclast differentiation [IDA, ISS, NAS]
- positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell activation [IDA]
- positive regulation of bone resorption [IDA]
- positive regulation of corticotropin-releasing hormone secretion [ISS]
- positive regulation of fever generation by positive regulation of prostaglandin secretion [ISS]
- positive regulation of homotypic cell-cell adhesion [IDA]
- positive regulation of intracellular signal transduction [IDA]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- tumor necrosis factor-mediated signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GOSR1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999999102 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999999102, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TNFSF11 GOSR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 1182812 | |
TNFSF11 GOSR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3046092 |
Curated By
- BioGRID