EXOC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
CLOCK
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- cellular response to ionizing radiation [IDA]
- chromatin organization [TAS]
- circadian regulation of gene expression [IDA, IMP, ISS]
- circadian rhythm [TAS]
- histone acetylation [IMP]
- negative regulation of glucocorticoid receptor signaling pathway [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- photoperiodism [TAS]
- positive regulation of NF-kappaB transcription factor activity [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- regulation of hair cycle [IMP]
- regulation of insulin secretion [ISS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription, DNA-templated [ISS]
- regulation of type B pancreatic cell development [ISS]
- response to redox state [IDA]
- spermatogenesis [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- histone acetyltransferase activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [ISS]
- DNA binding [IDA]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- histone acetyltransferase activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [ISS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999995492 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999995492, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EXOC1 CLOCK | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3129169 |
Curated By
- BioGRID