P2RX4
Gene Ontology Biological Process
- apoptotic signaling pathway [IDA]
- cation transmembrane transport [IDA]
- cellular response to ATP [IDA]
- endothelial cell activation [TAS]
- ion transmembrane transport [IDA]
- membrane depolarization [IDA]
- negative regulation of cardiac muscle hypertrophy [IMP]
- positive regulation of calcium ion transport [NAS]
- positive regulation of calcium ion transport into cytosol [IDA, IMP]
- positive regulation of calcium-mediated signaling [IDA, IMP]
- positive regulation of nitric oxide biosynthetic process [NAS]
- positive regulation of prostaglandin secretion [NAS]
- purinergic nucleotide receptor signaling pathway [IMP]
- regulation of blood pressure [IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of sodium ion transport [ISS]
- relaxation of cardiac muscle [IMP]
- response to ATP [IDA]
- response to fluid shear stress [IDA]
- sensory perception of pain [ISS]
- signal transduction [IDA]
- tissue homeostasis [NAS]
- transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
C17ORF62
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999979184 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999979184, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| P2RX4 C17ORF62 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9999 | BioGRID | 1190631 | |
| C17ORF62 P2RX4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8816 | BioGRID | 3175254 | |
| P2RX4 C17ORF62 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3095182 |
Curated By
- BioGRID