BTN2A1
Gene Ontology Biological Process
Gene Ontology Cellular Component
PLCB1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- G2/M transition of mitotic cell cycle [ISS]
- activation of meiosis involved in egg activation [ISS]
- cerebral cortex development [ISS]
- glutamate receptor signaling pathway [ISS]
- inositol phosphate metabolic process [TAS]
- insulin-like growth factor receptor signaling pathway [ISS]
- interleukin-1-mediated signaling pathway [IDA]
- interleukin-12-mediated signaling pathway [IDA]
- interleukin-15-mediated signaling pathway [IDA]
- memory [ISS]
- negative regulation of monocyte extravasation [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- phosphatidylinositol metabolic process [ISS]
- positive regulation of CD24 biosynthetic process [ISS]
- positive regulation of G1/S transition of mitotic cell cycle [ISS]
- positive regulation of GTPase activity [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of acrosome reaction [ISS]
- positive regulation of developmental growth [ISS]
- positive regulation of embryonic development [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of myoblast differentiation [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of G-protein coupled receptor protein signaling pathway [ISS]
- regulation of fertilization [ISS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999955201 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999955201, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
BTN2A1 PLCB1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9998 | BioGRID | 1186227 | |
BTN2A1 PLCB1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9998 | BioGRID | 3043344 |
Curated By
- BioGRID