BAIT
FAM189B
C1orf2, COTE1
family with sequence similarity 189, member B
GO Process (0)
GO Function (2)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
SMO
FZD11, Gx, SMOH
smoothened, frizzled class receptor
GO Process (19)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IBA]
- cellular response to cholesterol [ISS]
- detection of cell density by contact stimulus involved in contact inhibition [IMP]
- determination of left/right asymmetry in lateral mesoderm [ISS]
- forebrain morphogenesis [ISS]
- heart looping [ISS]
- mesenchymal to epithelial transition involved in metanephric renal vesicle formation [ISS]
- midgut development [ISS]
- negative regulation of DNA binding [ISS]
- negative regulation of gene expression [ISS]
- non-canonical Wnt signaling pathway [IBA]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of hh target transcription factor activity [ISS]
- regulation of heart morphogenesis [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, IMP]
- somite development [ISS]
- ventral midline determination [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.99995352 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.99995352, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID