EPHA7
Gene Ontology Biological Process
- brain development [ISS]
- branching morphogenesis of a nerve [ISS]
- ephrin receptor signaling pathway [IDA]
- negative chemotaxis [ISS]
- peptidyl-tyrosine phosphorylation [ISS]
- phosphorylation [ISS]
- positive regulation of neuron apoptotic process [ISS]
- regulation of ERK1 and ERK2 cascade [IDA]
- regulation of cell-cell adhesion [ISS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of protein autophosphorylation [ISS]
Gene Ontology Molecular Function
EPHA3
Gene Ontology Biological Process
- cell migration [ISS]
- cellular response to retinoic acid [IMP]
- ephrin receptor signaling pathway [IDA]
- fasciculation of motor neuron axon [ISS]
- fasciculation of sensory neuron axon [ISS]
- positive regulation of neuron projection development [IMP]
- regulation of Rho GTPase activity [IDA]
- regulation of actin cytoskeleton organization [IDA]
- regulation of epithelial to mesenchymal transition [ISS]
- regulation of focal adhesion assembly [IDA]
- regulation of microtubule cytoskeleton organization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999935474 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999935474, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
EPHA7 EPHA3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9998 | BioGRID | 3126664 | |
EPHA7 EPHA3 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0 | BioGRID | 3506311 |
Curated By
- BioGRID