OS9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AGRN
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [TAS]
- axon guidance [TAS]
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- clustering of voltage-gated sodium channels [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- phototransduction, visible light [TAS]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of synaptic growth at neuromuscular junction [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- receptor clustering [IDA, IMP]
- retinoid metabolic process [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synapse organization [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999878088 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999878088, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OS9 AGRN | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9996 | BioGRID | 3032450 |
Curated By
- BioGRID