NUFIP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDE2A
Gene Ontology Biological Process
- blood coagulation [TAS]
- cAMP catabolic process [IDA, IMP]
- cAMP-mediated signaling [IMP]
- cGMP catabolic process [IDA]
- cGMP-mediated signaling [IMP]
- calcium ion transmembrane transport [TAS]
- cellular response to cGMP [IDA]
- cellular response to drug [IEP, IMP]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to macrophage colony-stimulating factor stimulus [IDA]
- cellular response to mechanical stimulus [ISS]
- cellular response to transforming growth factor beta stimulus [IEP]
- establishment of endothelial barrier [ISS]
- metabolic process [IDA]
- monocyte differentiation [IEP]
- negative regulation of cAMP biosynthetic process [ISS]
- negative regulation of protein import into nucleus, translocation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of vascular permeability [IMP]
- positive regulation of inflammatory response [ISS]
- positive regulation of vascular permeability [IMP]
- protein targeting to mitochondrion [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999802911 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999802911, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NUFIP1 PDE2A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9864 | BioGRID | 1179670 | |
| NUFIP1 PDE2A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9826 | BioGRID | 3068795 |
Curated By
- BioGRID