IFNA14
Gene Ontology Biological Process
- B cell differentiation [IBA]
- B cell proliferation [IBA]
- T cell activation involved in immune response [IBA]
- adaptive immune response [IBA]
- blood coagulation [TAS]
- cytokine-mediated signaling pathway [IBA, TAS]
- humoral immune response [IBA]
- innate immune response [IBA, TAS]
- natural killer cell activation involved in immune response [IBA]
- positive regulation of peptidyl-serine phosphorylation of STAT protein [IBA]
- regulation of MHC class I biosynthetic process [IBA]
- regulation of type I interferon-mediated signaling pathway [TAS]
- response to exogenous dsRNA [IBA]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IFIT1
Gene Ontology Biological Process
- cellular response to exogenous dsRNA [IDA]
- cellular response to type I interferon [IDA]
- cytokine-mediated signaling pathway [TAS]
- intracellular transport of viral protein in host cell [IDA]
- negative regulation of defense response to virus by host [IDA]
- negative regulation of helicase activity [IDA]
- negative regulation of protein binding [IDA]
- negative regulation of viral genome replication [IMP]
- positive regulation of viral genome replication [IDA]
- response to virus [IDA, IMP]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999474975 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999474975, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IFNA14 IFIT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 1197557 | |
| IFNA14 IFIT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3094843 |
Curated By
- BioGRID