HCLS1
Gene Ontology Biological Process
- cellular response to cytokine stimulus [IMP]
- erythrocyte differentiation [ISS]
- intracellular signal transduction [TAS]
- negative regulation of leukocyte apoptotic process [IMP]
- positive regulation of actin cytoskeleton reorganization [IC]
- positive regulation of cell proliferation [ISS]
- positive regulation of granulocyte differentiation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of transcription factor import into nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of tyrosine phosphorylation of STAT protein [ISS]
- regulation of actin filament polymerization [IMP]
- regulation of transcription, DNA-templated [TAS]
- response to hormone [ISS]
Gene Ontology Molecular Function
SNX1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.998990546 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.998990546, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HCLS1 SNX1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9079 | BioGRID | 3244548 | |
| HCLS1 SNX1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9991 | BioGRID | 3107056 |
Curated By
- BioGRID