KCNA5
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [IMP]
- membrane hyperpolarization [IMP]
- potassium ion export [IDA, IMP]
- potassium ion transport [IDA]
- regulation of atrial cardiac muscle cell membrane repolarization [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of insulin secretion [TAS]
- regulation of membrane potential [IDA]
- regulation of potassium ion transport [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- alpha-actinin binding [IPI]
- delayed rectifier potassium channel activity [IDA, IMP]
- outward rectifier potassium channel activity [IDA, IMP]
- protein binding [IPI]
- protein kinase binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [IMP]
- alpha-actinin binding [IPI]
- delayed rectifier potassium channel activity [IDA, IMP]
- outward rectifier potassium channel activity [IDA, IMP]
- protein binding [IPI]
- protein kinase binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [IMP]
Gene Ontology Cellular Component
CYB5R1
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.998374552 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.998374552, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNA5 CYB5R1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9986 | BioGRID | 3140238 |
Curated By
- BioGRID