LZTFL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
BBS2
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [IMP]
- adult behavior [ISS]
- brain morphogenesis [ISS]
- cerebral cortex development [ISS]
- cilium morphogenesis [ISS]
- fat cell differentiation [ISS]
- hippocampus development [ISS]
- melanosome transport [ISS]
- negative regulation of appetite by leptin-mediated signaling pathway [ISS]
- negative regulation of multicellular organism growth [ISS]
- photoreceptor cell maintenance [ISS]
- protein localization [ISS]
- protein localization to organelle [ISS]
- regulation of cilium beat frequency involved in ciliary motility [ISS]
- sperm axoneme assembly [ISS]
- striatum development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.998370303 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.998370303, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LZTFL1 BBS2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| LZTFL1 BBS2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9998 | BioGRID | 1181465 | |
| LZTFL1 BBS2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9978 | BioGRID | 3091331 |
Curated By
- BioGRID