CASQ2
Gene Ontology Biological Process
- Purkinje myocyte to ventricular cardiac muscle cell signaling [NAS]
- cardiac muscle contraction [IMP]
- cellular response to caffeine [IMP]
- detection of calcium ion [TAS]
- ion transmembrane transport [TAS]
- negative regulation of potassium ion transmembrane transporter activity [ISS]
- negative regulation of potassium ion transport [ISS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA, ISS]
- protein polymerization [IDA]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IMP]
- regulation of cell communication by electrical coupling [IMP]
- regulation of heart rate [IMP]
- regulation of membrane repolarization [ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- sequestering of calcium ion [IDA, IMP]
- striated muscle contraction [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
PPP1R9A
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.998020787 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.998020787, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CASQ2 PPP1R9A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9826 | BioGRID | 1193303 | |
| CASQ2 PPP1R9A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9885 | BioGRID | 3111757 |
Curated By
- BioGRID