VSIG1
NF1
Gene Ontology Biological Process
- MAPK cascade [ISS]
- Ras protein signal transduction [ISS]
- Schwann cell development [ISS]
- actin cytoskeleton organization [ISS]
- adrenal gland development [ISS]
- artery morphogenesis [ISS]
- brain development [ISS]
- camera-type eye morphogenesis [ISS]
- cell communication [ISS]
- cerebral cortex development [ISS]
- cognition [IMP]
- collagen fibril organization [ISS]
- extracellular matrix organization [ISS]
- forebrain astrocyte development [ISS]
- forebrain morphogenesis [ISS]
- heart development [ISS]
- liver development [ISS]
- metanephros development [ISS]
- myelination in peripheral nervous system [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of MAPK cascade [IMP, ISS]
- negative regulation of Ras protein signal transduction [IBA]
- negative regulation of cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of neuroblast proliferation [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of protein kinase activity [ISS]
- negative regulation of transcription factor import into nucleus [ISS]
- osteoblast differentiation [ISS]
- peripheral nervous system development [ISS]
- phosphatidylinositol 3-kinase signaling [ISS]
- pigmentation [ISS]
- positive regulation of Ras GTPase activity [IDA, IMP, ISS]
- positive regulation of adenylate cyclase activity [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation of neuron apoptotic process [ISS]
- regulation of Ras GTPase activity [IMP]
- regulation of angiogenesis [IMP]
- regulation of blood vessel endothelial cell migration [IMP]
- regulation of bone resorption [ISS]
- regulation of cell-matrix adhesion [ISS]
- regulation of glial cell differentiation [ISS]
- response to hypoxia [ISS]
- smooth muscle tissue development [ISS]
- spinal cord development [ISS]
- sympathetic nervous system development [ISS]
- visual learning [ISS]
- wound healing [ISS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.996681031 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.996681031, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
VSIG1 NF1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9933 | BioGRID | 3059639 |
Curated By
- BioGRID