VTN
Gene Ontology Biological Process
- cell adhesion [TAS]
- cell adhesion mediated by integrin [IDA]
- cell-matrix adhesion [IDA]
- endodermal cell differentiation [IDA]
- extracellular matrix organization [TAS]
- immune response [TAS]
- innate immune response [TAS]
- negative regulation of blood coagulation [IC]
- negative regulation of endopeptidase activity [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of protein binding [IDA]
- positive regulation of receptor-mediated endocytosis [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [TAS]
- positive regulation of wound healing [IC]
- regulation of complement activation [TAS]
- smooth muscle cell-matrix adhesion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
POP4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.993605887 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.993605887, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
VTN POP4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9898 | BioGRID | 3083149 |
Curated By
- BioGRID