BAIT
SIX2
SIX homeobox 2
GO Process (15)
GO Function (0)
GO Component (5)
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- anterior/posterior axis specification [ISS]
- cell migration [IDA]
- cell proliferation [IDA]
- embryonic digestive tract morphogenesis [ISS]
- kidney development [IMP, ISS]
- mesenchymal cell differentiation involved in kidney development [ISS]
- mesenchymal stem cell maintenance involved in nephron morphogenesis [ISS]
- mesenchymal stem cell proliferation [ISS]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [ISS]
- mesodermal cell fate specification [ISS]
- nephron development [ISS]
- nephron morphogenesis [ISS]
- positive regulation of chondrocyte proliferation [ISS]
- regulation of branching involved in ureteric bud morphogenesis [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
MARK2
EMK-1, EMK1, PAR-1, Par-1b, Par1b
MAP/microtubule affinity-regulating kinase 2
GO Process (13)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- activation of protein kinase activity [TAS]
- establishment of cell polarity [IDA, TAS]
- establishment or maintenance of epithelial cell apical/basal polarity [IDA]
- intracellular signal transduction [IDA]
- mitochondrion degradation [NAS]
- mitochondrion localization [NAS]
- neuron migration [ISS]
- peptidyl-threonine phosphorylation [TAS]
- positive regulation of neuron projection development [IDA]
- protein autophosphorylation [ISS]
- protein phosphorylation [IDA, NAS]
- regulation of axonogenesis [IMP]
- regulation of cytoskeleton organization [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.970222811 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.970222811, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID