PTCH1
Gene Ontology Biological Process
- brain development [ISS]
- cellular response to cholesterol [IMP, ISS]
- dorsal/ventral pattern formation [ISS]
- embryonic limb morphogenesis [ISS]
- limb morphogenesis [IMP]
- negative regulation of multicellular organism growth [ISS]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of smoothened signaling pathway [ISS, TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural plate axis specification [ISS]
- neural tube patterning [IMP]
- organ morphogenesis [ISS]
- pharyngeal system development [IMP]
- positive regulation of cholesterol efflux [IDA]
- protein processing [ISS]
- protein targeting to plasma membrane [IDA]
- regulation of smoothened signaling pathway [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, ISS]
- somite development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ENPP1
Gene Ontology Biological Process
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process [IDA]
- ATP catabolic process [ISS]
- cellular phosphate ion homeostasis [IDA]
- cellular response to insulin stimulus [IDA]
- generation of precursor metabolites and energy [IDA]
- inorganic diphosphate transport [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of glucose import [IDA]
- negative regulation of glycogen biosynthetic process [IDA]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of protein autophosphorylation [IDA]
- nucleic acid phosphodiester bond hydrolysis [ISS]
- nucleoside triphosphate catabolic process [IDA]
- phosphate-containing compound metabolic process [IDA]
- regulation of bone mineralization [IC]
- riboflavin metabolic process [TAS]
- sequestering of triglyceride [IDA]
- small molecule metabolic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function- 3'-phosphoadenosine 5'-phosphosulfate binding [IC]
- ATP binding [IDA]
- calcium ion binding [ISS]
- insulin receptor binding [IDA]
- nucleoside-triphosphate diphosphatase activity [IDA]
- nucleotide diphosphatase activity [IDA, TAS]
- phosphodiesterase I activity [ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [ISS]
- 3'-phosphoadenosine 5'-phosphosulfate binding [IC]
- ATP binding [IDA]
- calcium ion binding [ISS]
- insulin receptor binding [IDA]
- nucleoside-triphosphate diphosphatase activity [IDA]
- nucleotide diphosphatase activity [IDA, TAS]
- phosphodiesterase I activity [ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [ISS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.967821785 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.967821785, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTCH1 ENPP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9565 | BioGRID | 1192138 | |
| PTCH1 ENPP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9576 | BioGRID | 3082700 |
Curated By
- BioGRID