SFRP2
Gene Ontology Biological Process
- cardiac left ventricle morphogenesis [IMP]
- cell-cell signaling [ISS]
- hematopoietic stem cell proliferation [ISS]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of dermatome development [ISS]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of epithelial to mesenchymal transition [IDA]
- negative regulation of gene expression [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- non-canonical Wnt signaling pathway [IBA]
- outflow tract morphogenesis [IMP]
- patterning of blood vessels [ISS]
- positive regulation of angiogenesis [ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of cell adhesion mediated by integrin [ISS]
- positive regulation of cell growth [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of fat cell differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of stem cell division [ISS]
- sclerotome development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MKLN1
Gene Ontology Biological Process
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.95623689 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.95623689, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SFRP2 MKLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9846 | BioGRID | 1181071 | |
| SFRP2 MKLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9206 | BioGRID | 3086008 |
Curated By
- BioGRID