BAIT
B3GAT3
GLCATI, glcUAT-I
beta-1,3-glucuronyltransferase 3
GO Process (10)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- chondroitin sulfate proteoglycan biosynthetic process [IDA]
- dermatan sulfate proteoglycan biosynthetic process [IDA]
- glycosaminoglycan biosynthetic process [IDA, NAS]
- glycosaminoglycan metabolic process [TAS]
- heparan sulfate proteoglycan biosynthetic process [IDA]
- positive regulation of catalytic activity [IDA]
- positive regulation of intracellular protein transport [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NLGN1
NL1
neuroligin 1
GO Process (36)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cytoskeletal matrix organization at active zone [ISS]
- establishment of protein localization [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- metabolic process [IBA]
- nervous system development [ISS]
- neurexin clustering [ISS]
- neuron cell-cell adhesion [ISS, TAS]
- neuronal signal transduction [TAS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of intracellular signal transduction [ISS]
- positive regulation of ruffle assembly [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- positive regulation of synaptic vesicle endocytosis [ISS]
- positive regulation of synaptic vesicle exocytosis [ISS]
- postsynaptic density protein 95 clustering [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein homooligomerization [ISS]
- protein localization to synapse [ISS]
- protein targeting [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of neuron differentiation [ISS]
- regulation of synaptic transmission [IBA]
- synapse assembly [IBA, ISS]
- synaptic vesicle clustering [ISS]
- synaptic vesicle targeting [ISS]
- terminal button organization [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.951261497 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.951261497, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID